Mesothelioma is one of the most deadly disease in the world. It is a cancer of the mesothelium of the abdominal cavity, the chest wall and the region around the heart. Different types of mesothelioma are distinguished between by where the cancer is growing.
Pleural mesothelioma, the most common, accounting for 75% of all mesothelioma cases, is where cancerous cells develop on the lining of the lungs. The next most common form of mesothelioma is peritoneal mesothelioma and this is where cancerous cells grow on the peritoneum which is the lining of the abdomen. Pericardial mesothelioma, the least common major form of mesothelioma, makes up roughly 5% of all mesothelioma cases. This is where malignant cancer cells grow on the lining of the heart.
Mesothelioma is primarily caused by chronic exposure to asbestos or asbestos related products. As asbestos fibers enter the body, either by breathing or swallowing, they cause normally healthy cells to mutate into cancer. This exposure can come directly, such as working in an asbestos processing center, or indirectly by inhalation of residual asbestos particles remaining on clothing or building materials. Due to its uncommon nature, mesothelioma is typically difficult to diagnose and treat. It has been connected with exposure to asbestos, a material formerly present in many work environments. Only about 3,000 individuals are diagnosed annually.
The primary risk factor for developing mesothelioma is exposure to asbestos. Between 70-80% of people diagnosed with mesothelioma have been exposed to asbestos, usually in the workplace. Although it is possible to develop mesothelioma without any exposure to asbestos, it is very rare.
While one person for every million people in the US will be diagnosed with mesothelioma, about 7-13 men who have been exposed to asbestos will be diagnosed with the disease. Symptoms frequently take 20 years to develop, but can take as long as 50 years to occur.
When cancerous cells invade the mesothelium, it becomes increasingly difficult to breathe. In the pleural form of mesothelioma, tumors growing in the mesothelium cause pleural effusions, which prevent the smooth movement of the lungs and other organs in the chest. Peritoneal mesothelioma invades the abdominal cavity and can cause loss of appetite weight loss, nausea and vomiting.
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